It is the 40s of the Shinka Era... In Japan, "superhumans" such as giant aliens, super robots, and monsters were active. While causing mysterious incidents, the "superhumans" at times stop destruction and save people. Jiro Hitoyoshi belongs to the "Superhuman Bureau," which works to register and protect such superhumans, and he has come to scout Kikko Hoshino, who is working as a server at a café. She is a "witch girl" type superhuman. And right in front of Jiro and Kikko, a battle between Grosse Augen, the superhuman of justice, and an "S" Planetarian unfolds, leaving Jiro and Kikko no choice but to join in the battle.

Fuurouta is a prank-loving ghost with transformation abilities. He became a bird at a department store in Ginza and let free a beautiful insect that was on sale. However, it was no average insect at all. The "Black Fog" that occurred at the same time flowed to Nagatacho and engulfed the area around the National Diet Building. Jiro and Kikko, who were handling the problem, meet Fuurouta at the police station and take him to the "Superhuman Bureau." Fuurouta gets interested in the bureau's activities and tries to go against the "Black Fog" in order to join...

Society was stunned by a case of serial bombings. Raito Shiba, a detective who exclusively handles superhuman cases, gets suspicious that there is nothing left behind at the scene. Raito guesses that employees of the military corporation Yatsuka Heavy Industry were attacked, and investigates the factory in Tachikawa. Then at a nearby park, he meets a girl named Mieko in a schoolgirl uniform. When the conflict worsens with the "Superhuman Bureau," which he has seen as an enemy for long, the surprising secret about Mieko comes to light. Raito, who had his life taken away by an evil organization and was made into a machine body, starts to get complicated feelings in his mind.

Throughout Japan, giant beasts rampage - products of pollution, warfare, and horrific experiments. Superhumans are building their reputations fighting the new threat, gaining the public's respect… and the attention of the Superhuman Bureau.

The beast broker has been taken down, and beast attacks are on the decline. However, when the corpse of a military beast goes missing, the Superhuman Bureau suspects that the beast-related incidents are not yet over.

The popular novelty band "Mountain Horses"... When "The Quartet" came to Japan and sold out the Nippon Budokan in June, the 41st of Shinka Era, they were playing as the opening band. Once the concert starts, the souls of the young people become liberated by the power of music. Is that the superhuman power that "The Quartet" has? Each of the Mountain Horses members who came into contact with them gain supernatural powers, but they were only usable for comedic purposes. Eventually, a conspiracy starts to progress, revolving around the superhuman powers that started to appear among the young people.

Earth-Chan has many powers, but the one power that drives her is the ability to determine good and evil. When help calls, Earth-Chan will rush to the rescue, but in a world where good and evil are unclear at best, who will Earth-Chan save?

The BL Clan, a group of juvenile superhumans, are a modern-day hero squad not affiliated with the Superhuman Bureau. However, when they tackle a case related to the Rainbow Knight, Jiro, a Rainbow Knight fan, cannot help but get involved.

The Superhuman Bureau encounters a strange family, who they suspect are completely immortal. Unlike other superhumans, they seem to be attracting unnecessary attention to themselves on purpose, and the Bureau seeks to find out why.

The Superhuman Bureau faces a new enemy, the Infernal Queen, an organization determined to kill everything it sees as evil. One of their own members, Hyouma "Jaguar" Yoshimura, seems to be involved in some way.

Another American superweapon is revealed to the public, but this time, its inhumane nature is revealed by a solo superhuman name Claude, not by the Superhuman Bureau. As controversy stirs, the Bureau members cannot agree on how to interpret this.

Murders targeting doctors and nurses have taken place in Sapporo. During the investigation of SPR children who manipulate magic and science, it is revealed that superhumans are used as guinea pigs for a horrible experiment. What is the goal of Wonder Sword Claude who is suspected as the mastermind? Kikko visits the Municipal Hakko High School when the heroic superhuman Galboi Riker who flew from the Soviet comes falling down in a horrid state. The students get a testimony saying he was shot down by the Self-Defense Force and the American superhuman Master Ultima, and rise up against the tyranny of the government.

The youth who had awakened to superhuman powers have shifted their sense of justice towards anti-war, anti-America, and anti-establishment, leading them to be called "Superhumanists." Human experimentation and at the Ogasawara Islands and governmental use of superhuman powers come to light. The enraged students rise up for a large-scale protest in Shinjuku, Tokyo in order to realize a "Superhuman Revolution." Jiro gets into action as well, to make Kikko back to normal after she transforms into the queen of the demon world. While Wonder Sword Claude works in stealth, will Jiro be able to follow through with his ideal of "Protect all superhumans"?